суббота, 15 марта 2008 г.

Testing!

ျမန္မာဖြန္႔စမ္းသပ္ျခင္း ..........

ေထြရာေလပါး ဘာညာသာရကာ အလာပသလာပ အေဆြးမ်ား အလြမ္းမ်ား မပါရ ..

четверг, 13 марта 2008 г.

Lecture Presentations

Biochemistry

1. Cells and Organelle
( click to download )
2. Proteins
3. Proteins ( continued )
4. Carbohydrates
5. Lipids
6. Nucleic Acid
7. Metabolism
8. Glycolysis
9. Citric Acid Cycle

Genetic
1. DNA, RNA
2. DNA replication, Repair and mutation
3. Transcription & RNA
4. Transcription & Regulation of gene expression

Our Teacher, Efimenko.A








T-cadherin suppresses angiogenesis in vivo by inhibiting migration of endothelial cells.

Department of Biological and Medical Chemistry, Faculty of Fundamental Medicine, Lomonosov Moscow State University, 31-5, Lomonosovsky av., Moscow, 119192, Russia. rksenia@cardio.ru

Our previous studies have revealed the abundant expression of T-cadherin--a glycosylphosphatidylinositol (GPI)-anchored member of cadherin superfamily--in endothelial and mural cells in the heart and vasculature. The upregulation of T-cadherin in vascular proliferative disorders such as atherosclerosis and restenosis suggests the involvement of T-cadherin in vascular growth and remodeling. However, the functional significance of this molecule in the vasculature remains unknown. The effect of T-cadherin on angiogenesis in vivo was evaluated using Matrigel implant model. We demonstrate that T-cadherin overexpression in L929 cells injected in Matrigel inhibits neovascularization of the plug. In vitro T-cadherin inhibits the directional migration of endothelial cells, capillary growth, and tube formation but has no effect on endothelial cell proliferation, adhesion, or apoptosis in vitro. These data suggest that T-cadherin expressed in the stroma could act as a negative guidance cue for the ingrowing blood vessels and thus could have an important potential therapeutic application.







2007 Noble Prize, Mario R.Capecchi!







Mario R. Capecchi, Ph.D., of the University of Utah, has won the 2007 Nobel Prize in Physiology or Medicine. Capecchi shares the prize with Oliver Smithies of University of North Carolina, Chapel Hill and Sir Martin Evans of Cardiff University in the UK.


The prize recognizes Capecchi’s pioneering work on “knockout mice” technology, a gene-targeting technique that has revolutionized genetic and biomedical research, allowing the creation of animal models for hundreds of human diseases.

Go to this link for futher reading http://learn.genetics.utah.edu/features/knockout/

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